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Clinical and animal studies have demonstrated the efficacy of benfotiamine in the treatment of diabetes-related neuropathy, kidney disease, peripheral vascular disease, and retinopathy (Stirban 2006

Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity (Davinelli et al., 2025) In ASD children, the oxidative stress is not only higher, but it manifests in a complicated new pattern concerning different types of ROS and antioxidants (Hirayama et al., 2020)

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Geng Y, Li L, Yan J, Liu K, Yang A, Zhang L, Shen Y, Gao H, Wu X, Noth I, Huang Y, Liu J, Fan X (2022b) PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis