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Current strategies focus not only on targeting the BBB endothelium but also on the effective transport of specific compounds across it and the subsequent targeted drug release at appropriate targets in the brain (32)

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Therefore, pharmacological doses of coenzyme Q 10 as high as 1,200 to 3,000 mg/day for adults and 30 mg/kg/day for children are usually needed to relieve symptoms in patients with coenzyme Q 10 deficiency (26)