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Adipocytes and bone marrow stromal cells in the TME can promote the resistance of tumor cells to ASNase treatment by supplying Gln and cysteine to leukemia cells, 348,349 and cancer-associated fibroblasts can secrete Asp to promote solid tumor growth

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One of the hormones they began to explore was GIP

2 shows the key signaling pathways involved in the regulation of IGFs in tumor progression

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