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GLP-1 drugs like Ozempic and Mounjaro have helped many people lose weight and manage type 2 diabetes, but a big question remains: what happens when people stop using them

The pharmaceutical design priorities emphasized efficacy with minimal liver toxicity and no aromatization to estrogen

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For example, GLP-1RAs can target invariant natural killer T (iNKT) cells and consequently reduce the production of proinflammatory cytokines such as IFN-, IL-2, IL-4, IL-10, IL-17, TNF-, and GM-CSF and possibly increase the production of anti-inflammatory cytokines such as IL-10

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