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For most patients, these effects are transient , with the greatest intensity occurring in the first 4-8 weeks of therapy

Less food intake and weight loss can reduce heat generation

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Sillence DJ Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

In animal research, combined use shows improved results: Quicker formation of granulation tissue and wound closure Decreased edema and inflammation Better tendon-to-bone integration and ligament tensile load Systemic effects on the protection of distant organs, such as the liver and kidney in ischemia-reperfusion

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