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Firstly, calprotectin recruits G9a histone methyltransferase to the TNF - promoter region via the RAGE receptor, leading to H3K9 demethylation and subsequently reducing TNF - secretion in LPSstimulated monocytes

For example, in an energy-restricted IF intervention using a modified fasting regimen of 5:2 (5 days normal feeding:2 days fasting), 12 weeks of energy restriction elicited approximately a 5% reduction in weight (62)

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