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Structural Changes of Gut Microbiota During Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

This would imply that molecular changes can be found prior to whole-muscle changes with heart failure and that IGF-I mRNA expression might be an early predictor of disruptions in muscle function[63]

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These findings support the concept that the microbiota indirectly modulates -cell subpopulations through the adipose tissueinflammationinsulin resistance and SCFA/LPSincretins-cells axes, even though direct single-cell studies demonstrating differential responses of individual -cell subtypes to microbiota-derived metabolites are not yet available (Doumatey et al., 2020)

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