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Therapeutic evaluation of ITP-LNP/siBACE1 in the treatment of Alzheimer disease To validate the potential of allosteric targeting in conditions associated with ectodomain shedding of target receptors and the possibility of applying other vectors, we explored the effectiveness of lipid nanoparticles for delivering siRNA-BACE1 for the treatment of Alzheimer disease (AD), in which the ectodomain of the IR in the cerebrovasculature is reportedly cleaved 26,27

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