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TB-500 is studied via cytoskeletal protein interaction rather than classical receptor binding: G-actin sequestration modulates actin polymerisation dynamics required for cell motility, migration, and structural remodelling

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97 Notably, GPX4 expression did not significantly affect TGF-1-induced EMT in A549 cells, nor did it reverse erastin-induced ferroptosis

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Overall, these studies indicate that glutamate may be unchanged or reduced, especially in more chronic cases, depending on the persistence of symptoms or other factors associated with long-term illness [29,30,31,32,33,34,35,36,37]