Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) binds at the AT 1 receptor subtype and mediates systemic blood pressure, body water/electrolyte balance and influences cerebral blood flow, cerebroprotection, seizure, stress and depression
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If they admit this directly, you can go ahead with a referral
Heterogeneity and Subgroup Analyses Low heterogeneity ( I =14%) was observed across studies, attributable to differences in baseline characteristics, comorbidity prevalence, and outcome definitions