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De Pietro S, Di Martino G, Caroprese M, Barillaro A, Cocozza S, Pacelli R, et al

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1.1 The first twincretin, Tirzepatide (LY3298176) The chemical formula of TZP is C225H348N48O68, a linear synthetic peptide composed of 39 aminoacids and with a molecular weight of about 48 KDa, which arises from the fusion of aminoacid sequences structurally similar to glucagon, human GIP, GLP-1, exendin-4