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whether and how this circuit might be impacted by GLP1R activation is unknown

Some people notice their appetite suppression feels strongest on days two through five after injection, with slight reduction in effect by day six or seven before the next dose

But the same trial flagged more atrial fibrillation, more blood clots, and, in a follow-up, more broken bones, most of them from ordinary falls, for reasons nobody has fully explained (New England Journal of Medicine, 2024)

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The latter study also identified lysosomes as a major post-endocytic GLP-1R destination, raising the possibility that prolonged agonist exposure might result in GLP-1R degradation

This can even be dangerous if your job involves the use of vehicles or heavy machinery