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Scientists are continuing to investigate its pharmacokinetics, metabolic pathways, long-term safety profile, and regulatory toxicology, but translating findings from laboratory and animal models into human applications is a significant challenge

Neurosci Lett 165(12):208210 Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, OCallaghan JP (2002) Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinsons disease

By slowing the movement of food through the digestive tract and making you feel fuller, weight loss medications can lead to significant weight loss

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If the problem is severe, amputation may be necessary