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This has led some researchers to test NAC in various animal models of inflammatory lung disease

Studies have demonstrated that lactate-induced autophagy activation can dictate cellular fate between survival and ferroptotic death based on the iron-handling capacity and antioxidant reserve of specific cell types (101,119,148)

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Notably, vitamin D receptor (VDR) expression is widespread in renal tubular and vascular smooth muscle cells, and its signaling appears to exert both protective and potentially adverse effects (3, 5)

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