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Description

Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury

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pmid:40183385 41

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Safety profiles differ significantly by compound and evidence base

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RNA-seq and transcriptomic analysis revealed that Auranofin and the combination with COJEC significantly downregulated pathways associated with tumor malignancy and metastatic capacity, such as MTORC1 signaling, glycolysis, Notch signaling, KRAS signaling, WNT- catenin signaling, hypoxia, angiogenesis, IL-6/JAK/STAT3 signaling, and epithelial-to-mesenchymal transition (Fig

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