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The most common side effect of GLP-1RAs is nausea and vomiting, which are hypothesized to result from inhibition of gastric emptying

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These findings add further support to a growing body of evidence that suggests that Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) may modulate the human reward system by interacting with receptors in brain regions associated with dopamine signaling

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These peptides send signals in the body

For example, hGLP-1 and OXM exhibit bias for cAMP over pERK1/2, whereas Ex-4 and GLP-1 [737] are not biased