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TNF- promotes Tumor Necrosis Factor Receptor 1 (TNFR1)-mediated internalization of GABA receptors, upregulates -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor expression, and enhances synaptic excitability, thereby triggering seizures and exacerbating emotional and cognitive dysfunction (Tripathi et al., 2024)

Future research aims to develop: With a growing body of evidence supporting the regenerative potential of stem cells in neurological and circadian disorders, insomnia is poised to become one of the earliest neurobehavioral conditions to benefit from personalized regenerative medicine [1-5]

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Patients considering this treatment should be aware of this distinction before proceeding