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1975 Feb 25;250(4):1422-26. [PMID: 1112810]

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Epididymosomes further deliver numerous proteins to sperm, including enzymes, chaperones, and structural proteins like sperm adhesion molecule 1, which participates in zona pellucida binding, prevents premature acrosome reaction, and protects against oxidative damage ( When sperm traverse the female reproductive tract, endometrial cell-derived EVs interact with the sperm surface