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Counterintuitive at first glance glucagon raises glucose but its hepatic effect (lipolysis stimulation, lipid catabolism boost, steatosis reduction) outweighs the hyperglycemic signal when paired with a strong GLP-1 arm

Expert Opinion On Pharmacotherapy, 16 (8), 12631274

A post-hoc analysis of STEP 1, 2, 3, and 5 found a small but statistically significant reduction in depressive symptoms with semaglutide compared to placebo

This is not a direct drug toxicity but a consequence of the treatment's metabolic effect

CV-anchored protocols will drive the bigger wave

Metabolic adaptations that defended higher body weight return when medication stops