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The analysis of the SURPASS trials of tirzepatide revealed no association between weight reduction and gastrointestinal adverse events (229)
Blood glucose, food intake, and major tissues including brown adipose, liver, and spleen weights were similar between RETA and SEMA, yet RETA uniquely reduced adiposity and delayed tumor latency suggesting that targeting a single receptor GLP1R was effective for many physiologic and metabolic benefits, but the additional agonism of GIPR and GPCR by RETA uniquely impacted adiposity, tumor onset, and tumor progression
Root Cause Resolution: It targets the three failures: Inflammation, Insulin Resistance, and ATP shortage
The findings suggest that GLP-1RAs may help address several of these treatment goals
inject slowly and steadily [8]
Delaying Progression of Diabetes-Related Nephropathy: Slows kidney damage associated with chronic diabetes
