Given that deficits in glutamate in cortical and limbic regions are implicated in MDD and causally related to depressive-like behaviors
Supporting Study: Pickart, L., & Margolina, A
Early signs of declining B12 levels include profound fatigue, tingling or numbness in extremities, cognitive changes, and balance problems requiring medical review

Date: April 17, 2014 Event: 29th Annual Science Student Research Symposium Location: Dickinson College Mansoor Ahmed Ghoto Differentiation induced apoptosis in AML cells: The role of p73 in p53-independent versus p53-mediated apoptosis Date: April 17, 2014 Event: 29th Annual Science Student Research Symposium Location: Dickinson College Rizwan Mohamed Saffie Differentiation induced apoptosis in AML cells: The role of p73 in p53-independent versus p53-mediated apoptosis Date: April 17, 2014 Event: 29th Annual Science Student Research Symposium Location: Dickinson College Harold Irvin Salmons Differentiation induced apoptosis in AML cells: The role of p73 in p53-independent versus p53-mediated apoptosis Date: April 17, 2014 Event: 29th Annual Science Student Research Symposium Location: Dickinson College Juliana Dee Schneider Differentiation induced apoptosis in AML cells: The role of p73 in p53-independent versus p53-mediated apoptosis Date: April 8, 2014 Event: American Association of Cancer Research (AACR) Annual Meeting Location: San Diego, CA Rizwan Mohamed Saffie Differentiation induced apoptosis in AML cells: The role of p73 in p53-independent versus p53-mediated apoptosis Date: April 8, 2014 Event: American Association of Cancer Research (AACR) Annual Meeting Location: San Diego, CA Harold Irvin Salmons Differentiation induced apoptosis in AML cells: The role of p73 in p53-independent versus p53-mediated apoptosis Date: February 21, 2014 Event: 14th Annual Biology Student Research Symposium Location: Dickinson Mansoor Ahmed Ghoto Inducing Cell Cycle Arrest and Apoptosis in Human Leukemia Cells: The Roles of c-Myc and p73

Glutathione deficiency is usually characterized by a reduction in the body's ability to detox, inability to repair DNA, increased cell mutations, increased oxidative stress and reduced oxygen and nutrients supply to cells
has been described as a normal condition that maximizes subcutaneous fat retention to ensure adequate caloric availability for pregnancy and lactation So it is completely natural, and exists for healthy biological reasons