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Subsequently, the phosphorylated SHP2 together with its adapter molecule growth factor receptor-bound protein 2 (Grb2) activates the downstream ERK signaling cascades, inducing thermogenesis by controlling sympathetic activity on BAT, and promoting the anorectic effects of leptin [136, 137]

Kardas et al., 2020)

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Preserve muscle through resistance training, high protein intake, and creatine supplementation

The research team came to the conclusion that supplementation of melanotan II can lead to a reduction in body mass without a drastic restriction in caloric intake [3]

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