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For more significant conditions, a medicinal dose of 0.5mg per kg is appropriate

For healthy research subjects, the mild water retention is not considered dangerous and is a sign of elevated GH levels

Lancet 392(10157):15191529 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB (2016) LEADER Steering Committee

While appetite suppression is the most visible effect, the underlying physiological impact on the kidneys is far more intricate

Study F0375G (n = 8) was a 27-month double-blind, placebo-controlled crossover trial including 6 months of mecasermin or placebo treatment, followed by a 3-month washout period, a 6-month crossover period, and a 12-month open-label extension study