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Some studies suggest that combining oral and topical glutathione can provide better brightening results than using either method alone. Certain formulations, such as liposomal or acetylated glutathione, are designed to improve stability and absorption, but clinical outcomes may differ between products

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Since it is highly reactive, its reaction rate is limited by diffusion

These nanomaterials are typically synthesized using plant or microbial reducing agents, avoiding toxic chemicals like sodium borohydride or hydrazine that are used in traditional methods [130, 151]

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