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The susceptibility of erythrocytes to eryptosis in glucose-6-phosphate dehydrogenase deficiency was attributed to oxidative stress [234], while in sickle cell disease Ca 2+ entry was reported to be facilitated by ceramide [233]

So you need a constant supply of antioxidants to switch off free radical damage

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The depletion of glycine specifically impairs the body's ability to synthesize new creatine and ATP, leaving the patient trapped in a state of persistent metabolic exhaustion

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10.1016/j.lfs.2023.121501 32 MaJ