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Other sGC stimulators and activators are currently in development for the treatment of CKD (NCT04507061, NCT04750577), with at least one study including participants with type 1 diabetes

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However, variable and limited responses highlight the cellular and molecular heterogeneity of HS, suggesting distinct inflammatory and fibrotic endotypes and limiting the effectiveness of a one-size-fits-all approach

Finally, for recording fatigue levels, the present study adopted BRAF-NRS Question 1 ( Future directions include prospective randomized controlled trials where the present findings are replicated with more detailed questionnaires and other tests for fatigue, depression, sleep, and stress