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Understanding Semaglutide Semaglutide, an FDA-approved GLP-1 receptor agonist, is prescribed for managing obesity and overweight adults with one or more weight-related conditions

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Adult study data In a head-to-head study in adults with type 2 diabetes, Victoza consistently outperformed Januvia 2 Primary endpoint: Mean change in A1C from baseline After 26 weeks Victoza vs Januvia vs Januvia Pratley (1860) Baseline A1C: 8.4% to 8.5% Studied in adults with type 2 diabetes taking metformin

These results imply a role of training on muscle carnosine metabolism, although a lack of gene or protein measurements hinders mechanistic interpretation of these findings