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However, much of the reported lean mass loss is actually from the liver and body water, not skeletal muscle

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Ania Jastreboff, an obesity medicine physician scientist at Yale University School of Medicine/Yale School of Medicine, co-Director of the Yale Center for Weight Management and the lead author on the phase 2 study, said that the results were striking and concluded that Retatrutide holds promise for substantial weight reduction in adults with obesity over a 48-week period

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But for most, he says, there's an element of negative reinforcement

From a safety perspective, unregulated peptides sold online are not subject to the quality controls, purity testing, or manufacturing standards required of licensed medicines