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Chandra S, Radwan MM, Majumdar CG, Church JC, Freeman TP, ElSohly MA

Semaglutide, also known by the brand names Wegovy and Ozempic, is a glucagon-like peptide-1 (GLP-1) receptor agonist used to lower blood sugar levels, weight loss, and to lower the risk of heart attack, stroke, or death in patients with type 2 diabetes, obesity, and heart disease

a washout period or a specific titration schedule is usually required to avoid severe side effects

The study tested several dose levels: 1 mg, 4 mg, 8 mg, and 12 mg

GLP-1RAs suppress hyperglycemia-induced proliferation, migration and apoptosis of VSMCs via suppressing the ERK1/2 and PI3K/Akt pathways [10]

doi: 10.1038/nchembio.209