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Although methylcobalamin and adenosylcobalamin are the bioactive forms of B12, they are unfortunately very chemically unstable outside of the body mainly due to their photosensitivity and therefore more difficult to produce

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Early biomarker response and patient preferences to oral and intramuscular vitamin B12 substitution in primary care: a randomised parallel-group trial

B12 is water-soluble and considered very safe, since excess is cleared by the kidneys

NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (TLR4-NF-B and STAT3-IL-1 pathways) linked to atherosclerosis, heart failure, and coronary heart disease

He finds it difficult to concentrate