Most published data derive from small pilot studies, in vitro experiments, and animal research, which substantially limits the conclusions that can be drawn
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload
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The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function
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Why it matters: Feeling full faster can reduce intake, but it can also mask dehydration or under-eating
