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Therapeutic potential of Semaglutide, a newer GLP-1 receptor agonist, in abating obesity, non-alcoholic steatohepatitis and neurodegenerative diseases: a narrative review

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It tends to concentrate around the midsection, comes with increased cravings and hunger, and is accompanied by other symptoms like sleep disruption and mood changes that make weight management even harder

DPP-4 enzyme inhibition has a well validated mechanism in diabetes treatment, with several small-molecule drugs on the market, including the Merck compound Sitagliptin (Figure 3)

Semaglutide contributes to weight loss primarily by mimicking the action of the incretin hormone GLP-1, which regulates appetite and calorie intake