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It seems that the reason carnitine was unable to increase muscle carnitine concentration in these studies for 2 reasons: Poor bioavailability (only 20% for of a 2-6 g dose is absorbed) and Because the transport of carnitine into the muscle was limited
The relative importance of canonical arrestin effects, that is, termination of G protein signalling and/or initiation of GPCR endocytosis, versus the establishment of G proteinindependent signalling cascades, is a matter of ongoing debate (Grundmann et al., 2018
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