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Obesity and HF often coexist with other comorbidities such as coronary artery disease, hypertension, and diabetes mellitus, further complicating a patients health status [10]

Even after approval, availability may depend on labeling, supply, prescriber adoption, and payer decisions

In clinical trials, tirzepatide has shown superior results in body weight reduction compared to other single-agent medications

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Al-Aly has described this as moving from food noise to drug noise, suggesting the same biological pathway that helps patients lose interest in overeating may also quiet the pull of alcohol, nicotine, opioids and other substances