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Lead group ( n = 10), free drink 0.2% lead acetate solution and 1 mL deionized water were intragastrical administered

Spacing doses prevents deficiencies and adverse effects

When IGF1 binding to IGF-IR/InsR is blocked by the anti-IGF-IR mAb cixutumumab, IGF1 binding to integrin v3 increases, resulting in activation of v3 and its downstream effectors Src, FAK, and PI3K, which confers cixutumumab resistance [172]

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