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When combined, these effects can paradoxically balance out for some patients, though nausea from tirzepatide usually dominates initially
Clinical trial data show patients typically regain a substantial portion of lost weight after discontinuation as appetite suppression reverses
In clinical trials, a higher percentage of QSYMIA-treated adults and pediatric patients aged 12 years and older experienced heart rate increases from baseline of more than 5, 10, 15, and 20 bpm compared to placebo-treated patients