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Incretins and SGLT2 inhibitors have been shown to be efficacious at further lowering glucose levels when combined with insulin therapy [81-94]

While they share a common mechanismmimicking the GLP-1 hormone to stimulate insulin secretion, suppress glucagon release, and slow gastric emptyingthey differ in their molecular structures, dosing schedules, efficacy, and side effect profiles

Its primarily produced in the intestines, pancreas, and hypothalamus area of the brain

Tirzepatide has a slightly higher cost than GLP-1 RAs for diabetes

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