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Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

The interventions involved titrated doses of glutathione over time, with full doses reached by week three, depending on individual tolerance

This medication may also slow gastric emptying after eating

Aggio, R

Drugs currently being tested that target AATs are shown in (Table 1)

Ohira, H., Tsutsui, W