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5/ GLP-1s prescribed for weight management 6/ Lifestyle change remains the foundation for all weight loss 7/ The bottom line Like the plot of a 2000s teen movie, GLP-1 medications are like the main character who starts at a new school and becomes popular overnight

[Crossref] [PubMed] Hohberger LA, Schroeder DR, Bartholmai BJ, et al

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This immunomodulatory effect was accompanied by significant anti-catabolic activity, as liraglutide reduced the activity of metalloproteinases and aggrecanases-key enzymes responsible for cartilage degradation [45] (Fig

Kaur J, Jialal I

In Global Health policy, the World Health Organisation (WHO) issued its first global guideline on the use of GLP-1 medicines in treating obesity in December 2025