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Factors that cause glutathione depletion and accelerate aging include: Nutrient-deficient diet Pollutants in the air and water Environmental toxins in food and personal care products Prescription medications and recreational drugs Chronic stress Trauma Infections Exposure to radiation Minimizing your exposure to harmful elements and optimizing healthy lifestyle behaviors can help prevent glutathione depletion

May have a role in supporting heart and brain function

CrossRef Cardiovascular autonomic neuropathy is associated with SLEDAI in patients with systemic lupus erythematosus Simin Guo, Yujiao Wang, Lingyun Sun Clinical Rheumatology.2025

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There is some evidence of a role for topiramate treatment off-label for eating disorders such as binge-eating disorder, for tics due to Tourettes syndrome or other chronic tic disorders, or for substance abuse disorders such as alcohol dependence