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IE roughly undergoes four stages, starting with the expansion of erythroid progenitors, followed by accelerated erythroid differentiation to the polychromatic erythrocyte stage, followed by blockage of polychromatic erythrocyte maturation and, finally, an increase in polychromatic erythrocyte death (Figure 1)

GlyNAC is a combination of glycine and N-acetylcysteine intended to provide substrates related to glutathione synthesis