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Erchen Decoctioncan also participate in the regulation of lipid metabolism in Zucker Diabetic Fatty Rats through the Insulin receptor substrate 1/protein kinase B/protein kinase A/hormone-sensitive lipase signaling pathway (IRS1/AKT/PKA/HSL signaling pathway) and this pathway is closely related to the levels of Prevotella , Ruminococcus , Blautia , Holdemania (Zhao et al., 2021)