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While this medication has demonstrated significant efficacy in clinical trials, it carries an FDA Boxed Warning regarding the risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

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(1979) Mechanism of alkaline hydrolysis of S-adenosyl-L-methionine and related sulfonium nucleosides, J

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As it was a Korea-customized clinical trial, the company set the obesity standard to suit the domestic guideline of BMI 25kg/