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Okuyama and H

However, it is not that simple

Cell Death Dis 12:500

The antioxidant activity of GSH intermediated via thiol (-SH) of its cysteine residue upon its interaction with ROS or electrophiles and the GSH oxidized to GSSG (oxidized Glutathione), the GSSG will reduce to GSH by Glutathione reductase (GR), the activity of GR is therefore very important to keep the antioxidant power of mammalian cells, while GSH/GSSG ratio is an indicator for redox balance in the cell

These studies suggest that the biologic mechanism underlying the differential improvements in patients with elevated IL-17 may be related to dopaminergic modulation of CNS inflammation, either directly or through modulation of dopamine synthesis and neurotransmission

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