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Article 9 mins How the Right Employee Wellbeing Strategy Impacts Microstress and Burnout at Work Burnout and languishing threaten individual and organizational productivity and business outcomes

Result: More Levodopa reaches the brain Increased and prolonged dopamine levels in CNS Reduces "wearing-off" effect Entacapone works only peripherally (does not cross BBB significantly)

What happens downstream when CXXC5 is blocked When PTD-DBM successfully prevents CXXC5 from binding Dishevelled, several downstream effects follow

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Proceedings of the National Academy of Sciences of the United States of America 110 , 1385713862, doi:10.1073/pnas.1307698110 (2013)