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Mechanistically, NETosis provides a biologically plausible link: NETs and NET-derived components (histones, MPO, NE, extracellular DNA) induce endothelial activation and dysfunction and promote platelet capture, fibrin deposition, and contact-pathway/coagulation activation, thereby converting neutrophil priming into endothelial injury and microvascular thrombotic events [69]

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10.1002/psp4.12683 8 BergstrandM.HookerA

Addiction is characterized by compulsive drug use despite awareness of the severe consequences it can cause