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To help with explanations, a brief summary of the methionine cycle, transsulfuration pathway, and connections to the folate cycle and Betaine (GB) pathway is provided in the next paragraph, and a schematic representation in figure 1

Additional studies are needed to determine which specific AOX or combination of AOXs offers the most benefit for managing this complex syndrome

Whilst we did not find this replicated in our meta-analysis in this particular brain region (nor in any of the individual studies included), nonetheless we did find this difference in the occipital region

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