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In type 2 diabetes mellitus model Bio-Breeding Zucker diabetic rat (BBZDR)/Wor rats, it is found that more than 84% of the brain regions show increased BBB permeability, while the cerebellum and midbrain do not change significantly [18]

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Immunofluorescence staining Sections were stained for keratin 19 (K19) (Developmental Studies Hybridoma Bank, TROMAIII), Zonula occludens-1 (ZO-1) (Abcam, ab96587), Vimentin (Abcam, ab92547), and 4,6-diamidino-2-phenylindole (DAPI) (D1306, Invitrogen), as previously described 67

Patients diagnosed with growth hormone deficiency or insufficiency may discover ipamorelin represents a valuable therapeutic option

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