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Still investigational: not FDA-approved, and patient counseling must reflect this

These are not comparable treatments

The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)

Intestinal inflammation, dysbiosis, or increased permeability can significantly reduce DAO production and allow dietary histamine to enter circulation unchecked

Anyway, focus on the positives I guess