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Those results, showing 28.7% weight loss at the 12mg dose, have generated enormous excitement and set a high bar for what TRIUMPH-1 might confirm in a broader obesity population

The titration schedule is as follows: 1-4 weeks : The dosage starts at 1 mg once weekly for 4 weeks

Changes in vision can include blurred vision or a temporary worsening of existing diabetic retinopathy, particularly during the early months of treatment or after dose increases

Having to stop mid-process to find a syringe or an alcohol wipe is how mistakes happen

What we can say is that the theoretical mechanism supports better lean mass retention, and early data is encouraging

The relevance of these findings to humans is unknown